The vast majority of students who attend Killester College live in the suburbs and parishes of Springvale, Keysborough, Noble Park, Mulgrave, Dandenong North, Endeavour Hills and Clayton. Total enrolment is approximately 800 students.
Killester College is a multicultural and multifaith school that reflects the demographic profile of the surrounding areas from which the school draws its students. Approximately 64% of students speak at least one language other than English.